Chief Clinical Advisor


Alex C. Spyropoulos, MD, FACP, FCCP, FRCPC is instrumental in the development of PCDS Anticoagulation (AC) decision support software.  He is currently a Professor of Medicine at the Zucker School of Medicine at Hofstra/Northwell, Professor at the Center for Health Innovations and Outcomes Research at the Feinstein Institute for Medical Research, and System Director of Anticoagulation Services and Clinical Thrombosis for the Northwell Health System in New York. He is a Fellow of the American College of Physicians, American College of Chest Physicians, International Academy of Clinical and Applied Thrombosis/Haemostasis, and Fellow of the Royal College of Physicians, Canada.


Dr. Spyropoulos has helped to develop protocols using LMWH in outpatient-based treatment of venous thromboembolic disease, patient self-testing of warfarin, perioperative “bridging” and management for patients on chronic oral anticoagulation, medical inpatient prophylaxis, protocols with regards to the use of anticoagulants for HIT, and clinical use of novel direct oral anticoagulants and in special patient populations.Dr. Spyropoulos has lectured extensively both nationally and internationally on these issues.  


He has been involved as Principal Investigator, Scientific Committee member, Steering and Executive Committee member, or member of Data Safety Monitoring Board in multiple international, multicenter randomized trials in thrombosis and anticoagulant therapy. He is a founding member of ATLAS, a US-based ARO-CRO in thrombosis-related research. He is a panel member of a US national experts consensus group for clinical excellence in thrombosis management, a member of the Anticoagulation Forum and the Thrombosis/Haemostasis Society of North America, co-Chair of the Scientific Standardization Committees of Perioperative Thrombosis and Haemostasis as part of International Society of Thrombosis and Haemostasis, and co-author for the 8th, 9th and currently 10th 2018 ACCP Guidelines on Perioperative Antithrombotic Therapy, the 2008 International Consensus Statement Guidelines in Venous Thromboembolism, and senior author for the 2013 International Consensus Statement on venous  thromboembolic disease. He is also a reviewer for the 2014 ESC Guidelines on Pulmonary Embolism. He is Section Editor for Thrombosis and Haemostasis, and is on the editorial staff for Hospital Medicine. He is a reviewer for many journals.


Dr. Spyropoulos’ research studies, articles, letters, and editorials have been published in over 170 peer-reviewed journals including The New England Journal of Medicine, Blood, Circulation, Annals of Internal Medicine, American Journal of Hematology, American Journal of Medicine, Chest, Thrombosis Haemostasis, American Journal of Cardiology, Journal of Thrombosis and Haemostasis , Journal of the American College of Cardiology, Clinical Applied Thrombosis and Haemostasis, and Thrombosis Research.